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KMID : 0361519990100020191
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Korean Journal of Psychopharmacology
1999 Volume.10 No. 2 p.191 ~ p.195
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A Case of Clozapine-Induced Eosinophilia Combined with Bilateral Pleural Effusion, Ascites, Cholecysctitis, and Hepatitis
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Hong Hyun-Ju
Kim Chan-Hyung
Song Dong-Ho
Lee Se-Joon
Lee Hong-Shick
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Abstract
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Several blood dyscrasias associated with clozapine have been well known to clinicians and potentially life threatening agranulocytosis has been widely reported. However, there is little report regarding incidence, progression and associated features of eosinophilia associated with clozapine. In clinical studies, the onset of eosinophilia usually occurs after 3 to 5 weeks of treatment and rarely were cases fatal with medical complication. We report the first case of severe eosinophilia, bilateral pleural effusion, asicites, hepatitis and cholecystitis associated with clozapine that would be fatal. Eosinophilia occurred after 19 days of treatment with clozapine and all the clinical conditions improved along with interruption of clozapine treatment. It is suggested that eosinophilia may be more severe side effect than has ever been known and close hematologic monitoring should be done during early treatment of clozapine.
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KEYWORD
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Clozapine, Eosinophilia,
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